Podoplanin Rat anti-Human, APC, Clone: NZ-1.3, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9381-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15538246

Quantity Price
1 £ 84.99 / 25 tests
EU Stock 7
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Description and Specification

Specification

Conjugate Allophycocyanin
Quantity 25 Tests
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Concentration 5μL (0.125μg)/test
Gene Alias PDPN
Antigen Podoplanin
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG2a
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Host Species Rat
Species Reactivity Human
Primary or Secondary Primary
Applications Flow Cytometry
Clone NZ-1.3

Podoplanin is a 40kDa type I transmembrane sialomucin-like glycoprotein involved in platelet aggregation and cancer metastasis. This protein is expressed on lymphatic endothelial cells and follicular dendritic cells, as well as on many human cancers, including squamous cell carcinoma, glioblastoma, seminoma, and mesothelioma. Podoplanin expression has been demonstrated to be regulated by the Fos protein of the Activating Protein-1 (AP-1) transcription factor complex. Much of its functionality arises via interaction with its endogenous receptor, C-type lectin-like receptor-2 (CLEC-2).

This antibody has been reported to block the interaction between Podoplanin and CLEC-2.