Invitrogen™ PODN Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531625

Product Code. 13496147

Description

Recommended positive controls: 293T, Jurkat. Predicted reactivity: Human (99%), Mouse (95%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Non-collagenous proteins of the small leucine-rich repeat (SLR) protein family are considered important components of the extracellular matrix. The extracellular matrix plays an integral role in the pivotal processes of development, tissue repair and metastasis by regulating cell proliferation, differentiation, adhesion and migration. Podocan, also known as PCAN, SLRR5A or PODN, is a 613 amino acid secreted protein belonging to the small leucine-rich proteoglycan (SLRP) family and the class V subfamily. Expressed in kidney, heart, liver, pancreas and vascular smooth muscle cells, Podocan exists as three alternatively spliced isoforms containing twenty LRR (leucine-rich repeats), a unique N-terminal cysteine-rich cluster pattern and a highly acidic C-terminal domain. Podocan is considered a glycoprotein containing N-linked oligosaccharides that may be involved in growth regulation in cardiovascular tissues. Encoded by a gene located on human chromosome 1, Podocan interacts type I collagen (COL1).

Specifications

• Antigen: PODN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Podn
• Gene Alias: 9430070G18; Pcan; Podn; Podocan; podocan proteoglycan; PRO332; SLRR5A; UNQ293; UNQ293/PRO332
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 127435
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.68 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q7Z5L7
• Gene Symbols: Podn
• Immunogen: Recombinant protein encompassing a sequence within the center region of human PODN. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG