Invitrogen™ PMEL Monoclonal Antibody (HMB45)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA134759

Product Code. 11534223

Description

This antibody reacts with an antigen present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells.This antibody reacts with melanomas and tumors showing melanoma/melanocytic differentiation. It reacts with junctional and blue nevus cells. Non-melanocytic cells do not react with this antibody.

Melanoma is a malignant tumor of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma). It is one of the rarer types of skin cancer but causes the majority of skin cancer related deaths.

Specifications

• Antigen: PMEL
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P40967
• Gene Symbols: PMEL
• Immunogen: Extract of pigmented melanoma metastases from lymph nodes.
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: HMB45
• Conjugate: Unconjugated
• Gene: PMEL
• Gene Alias: 95 kDa melanocyte-specific secreted glycoprotein; 95kDa melanocyte-specific secreted glycoprotein; D10H12S53E; D12S53E; D12S53Eh; gp100; gp87; M-alpha; M-beta; ME20; ME20M; ME20-M; ME20-S; Melanocyte lineage specific antigen GP100; melanocyte protein mel 17; melanocyte protein PMEL; Melanocyte protein Pmel 17; melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; P1; P100; P26; PMEL; Pmel 17; PMEL17; premelanosome protein; Secreted melanoma-associated ME20 antigen; SI; SIL; SILV; silver homolog; silver locus protein; silver locus protein homolog; silver, mouse, homolog of
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 6490
• Content And Storage: 4°C, do not freeze
• Form: Liquid