PLZF Mouse anti-Human, Mouse, PE, Clone: Mags.21F7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9320-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15289349

Quantity Price
1 £ 176.7 / 100µg
EU Stock 3
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Description and Specification

Specification

Antigen PLZF
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone Mags.21F7
Species Reactivity Human, Mouse
Format Conjugated
Conjugate PE
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Isotype IgG1
Concentration 0.2mg/mL
Monoclonal or Polyclonal Monoclonal
Gene Alias Zbtb16, Zinc finger and BTB domain-containing protein 16
Primary or Secondary Primary
Quantity 100μg
Regulatory Status RUO
Applications Flow Cytometry (Intracellular Staining)

This Mags.21F7 monoclonal antibody reacts with human and mouse promyelocytic leukemia zinc finger (PLZF), a member of the BTB-POZ family of transcription factors. Expression of this transcriptional repressor in immune cells differs between mice and humans. In mice, PLZF is highly expressed in immature CD1d-resricted NKT2 and NKT1 cells, and a subset of gamma delta (Vg1.1+Vd6.3+) T cells. Studies have also demonstrated expression of PLZF in non-invariant CD1d-restricted T cells, as well as non-CD1d-restricted innate T cells. In humans, PLZF is expressed in NK cells, gamma delta T cells, as well as CD4 and CD8+ T cells. PLZF is also expressed in MR1-specific mucosal-associated invariant T cells, as well as in MHC Class II-restricted T cells that develop via a thymocyte-thymocyte interaction in humans. PLZF exists as a homodimer or in complex with PLZP, and has been shown to be involved in the development of NKT cells, NK cell function, cellular quiescence, and growth suppression. Finally, PLZF has been shown to inhibit gene expression induced by retinoic acid receptor.