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STEMCELL Technologies PLX4032

Product Code. 17190202
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 17190202

Brand: STEMCELL Technologies 73334

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Description

MEK/ERK pathway inhibitor; Inhibits B-RAF

  • PLX4032 is an ATP-competitive inhibitor of the serine/threonine kinase B-RAF proto-oncogene, with IC50 values of 31 and 100 nM for the wild-type and V600E mutant forms respectively (Khazak et al.; Sala et al.)
  • Inhibits proliferation in colon, melanoma, and thyroid carcinoma cancer cell lines expressing B-RAF V600E, alone or in synergy with taxol, vinblastine, and oxaliplatin compounds (Khazak et al.)
  • Suppresses MEK and ERK phosphorylation downstream of B-RAF in melanoma cells with mutations at the V600 position, correlated with antiproliferative effects (Joseph et al.; Yang et al.)
  • Inhibits tumor growth in B-RAF V600E melanoma tumor xenograft models (Yang et al.)

Specifications

CAS 918504-65-1
Synonym RG-7204; Ro 51-85426; Vemurafenib; Zelboraf™
Quantity 50 mg
Molecular Formula C23H18ClF2N3O3S
Purity ≥98%
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