PLSCR1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16818763	Proteintech 11582-1-AP-20UL	20 μL
16808763	Proteintech 11582-1-AP-150UL	150 μL

Description

The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.

Specifications

• Antigen: PLSCR1
• Applications: Immunoprecipitation, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry, Flow Cytometry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Human, Rat
• Gene Accession No.: O15162, P58195, Q9JJ00
• Gene ID (Entrez): 117540, 22038, 5359
• Immunogen: PLSCR1 Fusion Protein Ag2172
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: PLSCR1

• Concentration: 0.46 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: MMTRA1B, phospholipid scramblase 1, PL scramblase 1, PLSCR1
• Gene Symbols: PLSCR1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody