PLEKHO1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 24883-1-AP-150UL

Product Code. 16813395

Description

CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha′, and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.

Specifications

• Antigen: PLEKHO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLEKHO1
• Gene Alias: C Jun binding protein, CK2 interacting protein 1, CKIP 1, CKIP1, CKIP-1, HQ0024c, JBP, OC120, PLEKHO1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51177, 67220
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.39 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q53GL0, Q9JIY0
• Gene Symbols: PLEKHO1
• Immunogen: PLEKHO1 Fusion Protein Ag19309
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG