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Invitrogen™ PLEKHO1 Polyclonal Antibody

Product Code. 12818952
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Quantity:
100 μg
Unit Size:
100µg
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12818952 100 μg 100µg
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Product Code. 12818952 Supplier Invitrogen™ Supplier No. PA520827

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human lung tissue lysate. PA5-20827 can be used with blocking peptide PEP-0941.

CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLEKHO1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PLEKHO1
Gene Accession No. Q53GL0, Q5BJM5, Q9JIY0
Gene Alias 2810052M02Rik; Casein kinase 2-interacting protein 1; C-Jun-binding protein; CK2 interacting protein 1; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; CKIP1; CKIP-1; HQ0024c; HQ0024c protein; JBP; Jun zipper-associated 2; Jza2; JZA-20; OC120; Osteoclast maturation-associated gene 120 protein; PH domain-containing family O member 1; pleckstrin homology domain containing O1; pleckstrin homology domain containing, family O member 1; pleckstrin homology domain-containing family O member 1; pleckstrin homology domain-containing family O member 1-like; PLEKHO1; RGD1311487; RP11-458I7.3; TNF intracellular domain-interacting protein
Gene Symbols PLEKHO1
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the carboxy terminus of human CKIP1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 310674, 51177, 67220
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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