Invitrogen™ Plasminogen Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA534677

Product Code. 15335591

Description

Recommended positive controls: Jurkat, Raji, K562, BCL-1, PC-12, Rat2, human plasma, mouse plasma, rat plasma. Predicted reactivity: Rat (80%), Dog (81%), Pig (80%), Rhesus Monkey (93%), Bovine (81%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.

Specifications

• Antigen: Plasminogen
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLG
• Gene Alias: Ab1-346; Activation peptide; AI649309; angiostatin; DKFZp779M0222; Pg; plasmin; plasmin heavy chain A; Plasmin heavy chain A, short form; Plasmin light chain B; plasminogen; PLG; RP1-81D8.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18815, 5340, 85253
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.18 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P00747, P20918, Q01177
• Gene Symbols: PLG
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Plasminogen. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

Product Identifier

• Plasminogen Antibody

Signal Word

• Warning

Hazard Category

• Skin sensitiser Category 1A

Hazard Statement

• H317-May cause an allergic skin reaction.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P272-Contaminated work clothing should not be allowed out of the workplace.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
• P362+P364-Take off contaminated clothing and wash it before reuse.

Supplemental information

• MIXTURE LIST-Contains : glycerol