Invitrogen™ PKP3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584574

Product Code. 16351525

Description

Immunogen sequence: FDDIDLPSAV KYLMASDPNL QVLGAAYIQH KCYSDAAAKK QARSLQAVPR LVKLFNHANQ EVQRHATGAM RNLI Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.

Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalization, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localization in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of ~87 kDa.

Specifications

• Antigen: PKP3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKP3
• Gene Alias: 2310056L12Rik; Pkp3; plakophilin 3; plakophilin 3b; plakophilin-3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11187
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry, Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y446
• Gene Symbols: PKP3
• Immunogen: Recombinant protein corresponding to Human PKP3. Recombinant protein control fragment (Product #RP-104169).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG