Invitrogen™ PKP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA553144

Product Code. 15731091

Description

Immunogen sequence: VGNGNLHRTS SVPEYVYNLH LVENDFVGGR SPVPKTYDML KAGTTATYEG RWGRGTAQYS SQKSVEERSL RHPLRRLEIS PDSSPERAHY THSDYQYSQR SQAGHTLHHQ ESRRAALLVP PRY Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 41%.

Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.

Specifications

• Antigen: PKP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKP2
• Gene Alias: 1200008D14Rik; 1200012P04Rik; AA516617; ARVD9; PKP2; Pkp2l; plakophilin 2; plakophilin-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5318
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q99959
• Gene Symbols: PKP2
• Immunogen: Recombinant protein corresponding to Human PKP2. Recombinant protein control fragment (Product #RP-89628).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG