Invitrogen™ PKN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA563553

Product Code. 15791322

Description

Immunogen sequence: DCIVNMDAPY PGFLSVQGLE FIQKLLQKCP EKRLGAGEQD AEEIKVQPFF RTTNWQALLA RTIQ Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.

PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Specifications

• Antigen: PKN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKN3
• Gene Alias: AW209115; BC034126; Pkn3; PKNBETA; protein kinase N3; protein kinase PKNbeta; protein kinase PKN-beta; protein-kinase C-related kinase 3; Serine/threonine-protein kinase N3; UTDP4-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29941
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6P5Z2
• Gene Symbols: PKN3
• Immunogen: Recombinant protein corresponding to Human PKN3. Recombinant protein control fragment (Product #RP-103324).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG