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Eurofins DiscoverX PKD2 Recombinant Human Protein, Active
Description
Two serine/threonine protein kinase D isoforms (PKD1 and PKD2), belonging to the polycystin family, are involved in protein-protein and protein-carbohydrate adhesion. The two isoforms are known to interact, and also thought to be ion channel regulators. PKD2 (PKD4, APKD2) bears closest homology with PKCμ and PKCν. Stimuli that activate PKD2 include phorbol esters, gastrin, and classical and novel PKC family members. Defects in PKD (inhibition of function) is responsible for human autosomal dominant polycystic kidney disease (ADPKD) that causes progressive renal failure and may also lead to liver cysts.
GenBank NM_016457
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molecular Weight (g/mol) | 100 kDa |
| Quantity | 10 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal 6His |
| Expression System | Recombinant enzyme expressed in Sf21 insect cells |
| Protein Form | Full-length |
| Purity or Quality Grade | ≥46% |
| Protein | PKD2, active |
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