Invitrogen™ PIWIL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA523438

Product Code. 13297868

Description

The amino acid sequence used as immunogen is 100% homologous in rat, 87% homologous in human and dog, and 81% homologous in opossum.

The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.

Specifications

• Antigen: PIWIL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Piwil2
• Gene Alias: 80kDa PIWIL2 short isoform; cancer/testis antigen 80; CT80; HILI; mili; Miwi like; Miwi likw; piwi like homolog 2; piwi like RNA-mediated gene silencing 2; PIWIL1L; Piwil2; PIWI-L2; piwil2-like protein; piwi-like 2; piwi-like homolog 2; piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; testicular tissue protein Li 141
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57746
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: Q8CDG1
• Gene Symbols: Piwil2
• Immunogen: A portion of amino acids 30 to 80 of mouse Mili.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG