Invitrogen™ PITX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595968

Product Code. 16528811

Description

Immunogen sequence: MNCMKGPLHL EHRAAGTKLS AVSSSSCHHP QPLAMASVLA PGQPRSLDSS KHRLEVHTIS DTSSPEAAEK DKSQQGKNED VGAEDPSKKK RQRRQRTHFT; Positive Samples: NCI-H490, HeLa, Mouse brain, Rat brain ; Cellular Location: Nucleus.

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

Specifications

• Antigen: PITX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PITX2
• Gene Alias: 9430085M16Rik; all1-responsive gene 1; ALL1-responsive protein ARP1; Arp1; Brx1; BRX1 homeoprotein; Brx1b; Homeobox protein PITX2; homeodomain transcription factor 2; IDG2; IGDS; IGDS2; IHG2; IRID2; Munc30; orthodenticle-like homeobox 2; Otlx2; paired like homeodomain 2; paired like homeodomain transcription factor 2; paired-like homeodomain 1; paired-like homeodomain 2; paired-like homeodomain transcription factor 1; paired-like homeodomain transcription factor 2; paired-like homeodomain transcription factor 2c; paired-like homeodomain transcription factor Munc 30; Pituitary homeobox 2; PITX1; Pitx2; Pitx-2; Pitx2c; Ptx2; Rgs; Rieg; RIEG bicoid-related homeobox transcription factor; rieg bicoid-related homeobox transcription factor 1; RIEG1; rPtx2; RS; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S a 1 glycoprotein; S a1glycoprotein; Solurshin
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18741, 5308, 54284
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.22 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P97474, Q99697, Q9R0W1
• Gene Symbols: PITX2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Pituitary homeobox 2 (PITX2) (NP_0003162).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG