Invitrogen™ PIK3C2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5117137

Product Code. 17279633

Description

Positive Samples: SKOV3, HepG2 Immunogen sequence: MAQISSNSGF KECPSSHPEP TRAKDVDKEE ALQMEAEALA KLQKDRQVTD NQRGFELSSS TRKKAQVYNK QDYDLMVFPE SDSQKRALDI DVEKLTQAEL EKLLLDDSFE TKKTPVLPVT PILSPSFSAQ LYFRPTIQRG QWPPGLPGPS TYALPSIYPS TYSKQAAFQN GFNPRMPTFP STEPIYLSLP GQSPYFSYPL.

The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enyzmes have been linked to diverse, receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Specifications

• Antigen: PIK3C2A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PIK3C2A
• Gene Alias: C2-containing phosphatidylinositol kinase; CPK; Cpk-m; DKFZp686L193; MGC142218; p170; phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; phosphoinositide 3-kinase-C2-alpha; phosphoinositide-3-kinase, class 2, alpha polypeptide; PI3KC2; PI3-K-C2(ALPHA); pi3kc2a; PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; Pik3c2a; ptdIns-3-kinase C2 subunit alpha
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18704, 361632, 5286
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 5.36 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00443, Q61194
• Gene Symbols: PIK3C2A
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PIK3C2A (NP_0026362).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG