Piclamilast, Tocris Bioscience™

Description

Potent and selective PDE4 inhibitor

Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).

Specifications

• CAS: 144035-83-6
• Molecular Formula: C18H18Cl2N2O3
• Quantity: 10mg
• Synonym: piclamilast, cpodpmb, 3-cyclopentyloxy-n-3,5-dichloropyridin-4-yl-4-methoxybenzamide, unii-wm58d7c3zt, 3-cyclopentyloxy-n-3,5-dichloro-4-pyridinyl-4-methoxybenzamide, wm58d7c3zt, benzamide, 3-cyclopentyloxy-n-3,5-dichloro-4-pyridinyl-4-methoxy, chembl42126, 3-cyclopentyloxy-n-3,5-dichloro-4-pyridyl-p-anisamide, 3-cyclopentyloxy-n-3,5-dichloro-4-pyridyl-4-methoxybenzamide
• InChI Key: RRRUXBQSQLKHEL-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C(=O)NC2=C(C=NC=C2Cl)Cl)OC3CCCC3
• IUPAC Name: 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
• Molecular Weight (g/mol): 381.253
• PubChem CID: 154575
• ChEBI: CHEBI:47619
• Formula Weight: 381.25
• Percent Purity: >99%
• Chemical Name or Material: Piclamilast