Invitrogen™ Human PI4K2A (PI4K2 alpha), GST Tag Recombinant Protein

Product Code.	Quantity	unitSize
15950313	20 μg	20µg
17168755	100 μg	100µg
17138805	1 mg	1mg

Product Code. 15950313 Supplier Invitrogen™ Supplier No. A31079

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This PI4K2A (PI4K2 alpha) recombinant human protein (full length) was expressed in insect cells. PI4K2A (PI4K2 alpha) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the Adapta™ assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active The gene accession number for PI4K2A (PI4K2 alpha) is NP_060895.1.

PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation.

Specifications

• Accession Number: Q9BTU6
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 0.1mM EDTA, 0.1mM PMSF, 150mM NaCl, 10mM glutathione, 0.25mM DTT, 25% glycerol and no preservative; pH 7.5
• Gene ID (Entrez): 55361
• Molecular Weight (g/mol): 80.3 kDa
• Name: Human PI4K2A (PI4K2 alpha), GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 20 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 55 kDa type II phosphatidylinositol 4-kinase; null; phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase type 2 alpha; phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase type II (PI4KII); phosphatidylinositol 4-kinase type II-alpha; Pi4k2; PI4K2A; Pi4kii; PIK42A
• Common Name: PI4K2A
• Gene Symbol: Pi4k2a
• KinaseFamily: PI3 Kinase
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Full Length, Recombinant, Active
• Form: Liquid