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Eurofins DiscoverX PI3 Kinase (p110α(E545K)/p85α) Human Protein

Product Code. p-7228269
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Quantity:
10 μg
250 μg
Unit Size:
10µg
250µg
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Product Code. 17320714

Brand: Eurofins DiscoverX 14783

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This item is not returnable. View return policy

Description

Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K and untagged, recombinant, full-length human p85α, for use in Kinase Assays.

The E545K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation.

GenBank U79143 / GenBank XM_043865

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 125.3 kDa (p110α(E545K) and 83.7 kDa (p85α)
Quantity 10 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal 6His / Untagged
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Full-length
Purity or Quality Grade Combined ≥67%
Protein PI 3-Kinase (p110a(E545K)/p85a)
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