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Eurofins DiscoverX PI 3-Kinase (p110α(H1047R)/p85α) Human Protein

Product Code. 17390724
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Quantity:
10 μg
250 μg
Unit Size:
10µg
250µg
This item is not returnable. View return policy

Product Code. 17390724

Brand: Eurofins DiscoverX 14792M

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This item is not returnable. View return policy

Description

Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R, and untagged, recombinant, human p85α full length.

The H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation.

GenBank U79143 / GenBank XM_043865

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 129 kDa(p110α(H1047R)) and 83.6 kDa (p85α)
Quantity 250 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal 6His / Untagged
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Full-length
Purity or Quality Grade p110a ≥36 & p85a ≥34 Combined ≥70%
Protein PI 3-Kinase (p110α(H1047R)/p85α)
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