Invitrogen™ PHYHD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5121077

Product Code. 17752474

Description

Positive test controls include: Mouse spleen, Mouse liver, Mouse kidney, Mouse heart, Mouse skin, Rat liver, Rat kidney. Immunogen sequence: MACLSPSQLQ KFQQDGFLVL EGFLSAEECV AMQQRIGEIV AEMDVPLHCR TEFSTQEEEQ LRAQGSTDYF LSSGDKIRFF FEKGVFDEKG NFLVPPEKSI NKIGHALHAH DPVFKSITHS FKVQTLARSL GLQMPVVVQS MYIFKQPHFG GEVSPHQDAS FLYTEPLGRV LGVWIAVEDA TLENGCLWFI PGSHTSGVSR RMVRAPVGSA PGTSFLGSEP ARDNSLFVPT PVQRGALVLI HGEVVHKSKQ NLSDRSRQAY TFHLMEASGT TWSPENWLQP TAELPFPQLY T.

PHYHD1 (phytanoyl-CoA dioxygenase domain containing 1) is a 291 amino acid protein belonging to the PHYH family and the PHYHD1 subfamily. Encoded by a gene that maps to human chromosome 9q34.11, PHYHD1 exists as three alternatively spliced isoforms and likely functions as an alpha-ketoglutatare-dependent dioxygenase. PHYHD1 participates in metal ion binding and oxidoreductase activity, thereby acting on single donors with incorporation of two atoms of oxygen. Related to PHYH (phytanoyl-CoA 2-hydroxylase), an Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase that catalyzes the initial alpha-oxidation step in the degradation of phytenic acid in peroxisomes, PHYHD1 similarly exhibits additional homologues in a wide range of metazoans and bacteria. PHYHD1 also may play a role in DNA methylation in early postnatal liver development and mammalian differentiation.

Specifications

• Antigen: PHYHD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHYHD1
• Gene Alias: Phyhd1; phytanoyl-CoA dioxygenase domain containing 1; phytanoyl-CoA dioxygenase domain-containing protein 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 227696, 254295, 296621
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.55 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q5BJP9, Q5SRE7, Q9DB26
• Gene Symbols: PHYHD1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-291 of human PHYHD1 (NP_001094346.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG