Invitrogen™ Phospho-ZIPK (Thr265) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA540234

Product Code. 15556921

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Specifications

• Antigen: Phospho-ZIPK (Thr265)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAPK3
• Gene Alias: DAP kinase 3; DAP3K; Dapk3; Dapkl; DAP-like kinase; death associated protein kinase 3; death-associated kinase 3; Death-associated like kinase; death-associated protein kinase 3; DLK; MYPT1 kinase; ZIP; ZIP kinase; ZIP kinase isoform; Zipk; ZIP-kinase; zipper-interacting protein kinase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13144, 1613, 64391
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O43293, O54784, O88764
• Gene Symbols: DAPK3
• Immunogen: Synthesized peptide derived from human DAPK3 around the phosphorylation site of T265.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG