Invitrogen™ Phospho-ZAK (Ser165) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5105924

Product Code. 16652365

Description

Antibody detects endogenous levels of ZAK only when phosphorylated at Ser165.

ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Specifications

• Antigen: Phospho-ZAK (Ser165)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K20
• Gene Alias: AV006891; AZK; B230120H23Rik; HCCS4; HCCS-4; Human cervical cancer suppressor gene 4 protein; leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; Map3k20; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; mixed lineage kinase-related kinase; mixed lineage kinase-related kinase MRK-beta; MLK7; mlklak; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MLT; MLTK; MLTKalpha; MLTKbeta; MRK; pk; RGD1561394; SFMMP; sterile alpha motif and leucine zipper containing kinase AZK; sterile alpha motif- and leucine zipper-containing kinase AZK; sterile-alpha motif and leucine zipper containing kinase AZK; ZAK
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 311743, 51776, 65964
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9ESL4, Q9NYL2
• Gene Symbols: MAP3K20
• Immunogen: A synthesized peptide derived from human MAP3K20(Accession Q9NYL2), corresponding to amino acid residues around phosphorylated Ser165.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG