Invitrogen™ Phospho-WRN (Ser1141) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA538932

Product Code. 15565841

Description

Phospho-WRN (Ser1141) Polyclonal Antibody for Western Blot

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Specifications

• Antigen: Phospho-WRN (Ser1141)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: WRN
• Gene Alias: AI846146; DKFZp686C2056; DNA helicase, RecQ-like type 3; exonuclease WRN; RecQ protein-like 2; RecQ3; RECQL2; RECQL3; RGD1564788; similar to Werner syndrome helicase homolog; Werner syndrome ATP-dependent helicase; Werner syndrome ATP-dependent helicase homolog; Werner syndrome homolog (human); Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like; WRN
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7486
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14191
• Gene Symbols: WRN
• Immunogen: A synthetic phosphopeptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141 (S-S-SP-Q-P).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG