Invitrogen™ Phospho-VDR (Ser208) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104790

Product Code. 16671235

Description

Antibody detects endogenous levels of Vitamin D Receptor only when phosphorylated at Serine 208.

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.

Specifications

• Antigen: Phospho-VDR (Ser208)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VDR
• Gene Alias: 1,25-dihydroxyvitamin D3 receptor; HGNC:12679; I79_025795; Nr1i1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; protein phosphatase 1, regulatory subunit 163; vdr; vdr.S; vdr-A; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25- dihydroxyvitamin D3) receptor S homeolog; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; vitamin D receptor protein; vitamin D receptor S homeolog; Vitamin D3 receptor; XELAEV_18015993mg; xVDR
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7421
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P11473
• Gene Symbols: VDR
• Immunogen: A synthesized peptide derived from human VDR(Accession P11473), corresponding to amino acid residues around phosphorylated Ser208.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG