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Phospho-TK1 (Ser13) Polyclonal Antibody, Invitrogen™

Product Code. 15575261
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Quantity:
100 μg
Unit Size:
100µg
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15575261 100 μg 100µg
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Product Code. 15575261 Supplier Invitrogen Supplier No. PA538340

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Description

Rabbit Polyclonal Antibody

Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. High levels of these enzymes are present in proliferating cells, and low levels are found in resting cells, due to multiple regulatory mechanisms that ensure exclusive expression of these enzymes in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-TK1 (Ser13)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TK1
Gene Accession No. P04183, P04184
Gene Alias EC 2.7.1.21, KITH, TK-1, TK1, Thymidine kinase, cytosolic
Gene Symbols TK1
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human TK around the phosphorylation site of Ser13 (P-G-SP-P-S)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21877, 7083
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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