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Invitrogen™ Phospho-TAOK1/TAOK2/TAOK3 (Ser181, Ser177) Recombinant Rabbit Monoclonal Antibody (K01_2L19)

Product Code. 30828810
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30828810 50 μL
30830092 100 μL
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Product Code. 30828810 Supplier Invitrogen™ Supplier No. MA565442

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Description

Rabbit Recombinant Monoclonal Antibody

Phospho-TAOK1/TAOK2/TAOK3 (Ser181, Ser177) Recombinant Monoclonal Antibody for IHC (P), Western Blot

TAOK kinases, including TAOK1, TAOK2, and TAOK3, are serine-threonine kinases that belong to the sterile 20 (STE20) family and play significant roles in various cellular processes, including proliferation, apoptosis, and tumor progression. TAOK1 is implicated in neurodevelopmental disorders and has an evolving phenotype and genotype spectrum, which includes associations with macrocephaly and autism spectrum disorders. The TAOK2 gene, located on chromosome 16, is a crucial kinase participating in the regulation of protein translation through the phosphorylation of eukaryotic elongation factor 2 (eEF2) and is also involved in neurodevelopmental pathways. Moreover, TAOK2 acts as a potential tumor suppressor, with its downregulation linked to cancer progression in numerous types of cancer. TAOK3, another member of this kinase family, is expressed ubiquitously and has been linked to the regulation of age-associated inflammation, acting through pathways that limit pro-inflammatory monocyte accumulation. Additionally, TAOK3 is involved in osteoblast differentiation and modulates T cell receptor signaling by influencing components like SHP-1 and LCK. All three kinases are crucial for maintaining cellular homeostasis and their aberrations can lead to pathological conditions, particularly related to neurodevelopment and cancer.
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Specifications

Antigen Phospho-TAOK1/TAOK2/TAOK3 (Ser181, Ser177)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone K01_2L19
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 0.05% BSA, 40% glycerol, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene TAOK1
Gene Accession No. O88664, Q53UA7, Q5F2E8, Q6ZQ29, Q7L7X3, Q8BYC6, Q9H2K8, Q9JLS3, Q9UL54
Gene Symbols TAOK1, TAOK2, TAOK3
Host Species Rabbit
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1.
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216965, 286993, 304530, 330177, 381921, 51347, 57551, 64666, 9344
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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