Phospho-STAT5 (Y694) Mouse anti-Human, Mouse, PE, Clone: SRBCZX, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9010-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15507156

Quantity Price
1 £ 80.62 / 25 tests
EU Stock 4
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Description and Specification

Specification

Applications Flow Cytometry (Intracellular Staining)
Species Reactivity Human, Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen Phospho-STAT5 (Y694)
Gene Alias signal transducer and activator of transcription 5, pSTAT5
Isotype IgG1
Conjugate PE
Monoclonal or Polyclonal Monoclonal
Clone SRBCZX
Format Conjugated
Host Species Mouse
Concentration 5μL (0.25μg)/test
Quantity 25 tests
Regulatory Status RUO

This SRBCZX monoclonal antibody recognizes signal transducer and activator of transcription 5 (STAT5) when phosphorylated on tyrosine 694. STAT proteins are activated by ligand binding to receptors, such as cytokine receptors, that associate with Janus kinase (JAK) family members. Following their phosphorylation by JAKs, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner. In response to cytokines that signal through the common gamma chain such as IL-2, IL-7, and IL-15, STAT5 is phosphorylated on tyrosine 694 by JAK1 and JAK3. Cytokines such as IL-3, IL-5, and GM-CSF that signal via the common beta chain induce STAT5 phosphorylation on tyrosine 694 by JAK 2. Phosphorylation of STAT5 on tyrosine 694 is essential for STAT5 dimer formation, nuclear translocation, and DNA binding activity.

Specificity of this SRBCZX clone was determined by ELISA and flow cytometry.