Invitrogen™ Phospho-STAT5 alpha/beta (Ser726, Ser731) Polyclonal Antibody

Rabbit Polyclonal Antibody

Marke:  Invitrogen™ PA536767

Catalog No. 15574051

Beschreibung

This antibody detects endogenous protein at a molecular weight of 90 kDa. Purity is >95% by SDS-PAGE.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Spezifikation

• Antigen: Phospho-STAT5 alpha/beta (Ser726, Ser731)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STAT5A
• Gene Alias: AA959963; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; mammary gland factor; transcription factor; MGF; Mpf; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5a; Signal transducer and activator of transcription 5B; STA5B; STAT; STAT5; Stat5a; Stat5b; transcription factor STAT5B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20850, 20851, 24918, 25126, 6776, 6777
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P42229, P42230, P42232, P51692, P52632, Q62771
• Gene Symbols: STAT5A, STAT5B
• Immunogen: Synthetic phosphopeptide derived from human Stat5a around the phosphorylation site of Serine 726.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG