Invitrogen™ Phospho-SHC (Tyr239, Tyr240) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA517712

Product Code. 11522610

Description

It is not recommended to aliquot this antibody.

Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.

Specifications

• Antigen: Phospho-SHC (Tyr239, Tyr240)
• Classification: Polyclonal
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P29353, P98083, Q5M824
• Gene Symbols: SHC1
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pTyr239/240 of human Shc.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Gene: SHC1
• Gene Alias: FLJ26504; OTTHUMP00000035472; p66; P66shc; RP11-307C12.1; SH2 domain protein C1; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC adaptor protein 1; SHC1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; src homology 2 domain-containing transforming protein C1; src homology 2 domain-containing-transforming protein C1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20416, 6464, 85385
• Content And Storage: -20°C
• Form: Liquid