Invitrogen™ Phospho-RSK3 (Thr356, Ser360) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA585802

Product Code. 16312735

Description

Keep as concentrated solution. Predicted reactivity: Mouse (100%), Rat (100%), Bovine (100%). Positive Control: Neuro2A, NIH-3T3, Raw264.7, C2C12, NIH-3T3 (starvation for 16 hr), NIH-3T3 (starvation for 16 hr and 100 ng/ml PDGF treatment for 5 min), EGF treated A431. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RPS6KA2 (RSK3) serine/threonine kinase is a member of the ribosomal S6 kinase (RSK) family. It is believed that RPS6KA2 is a signal-transducing intermediate in the cellular response to several growth factors. It is found in many tissues, but in higher levels in lung and skeletal muscle. The p90 ribosomal S6 kinases (RSK)1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits and may have a tonic regulation on G-protein coupled signaling.

Specifications

• Antigen: Phospho-RSK3 (Thr356, Ser360)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RPS6KA2
• Gene Alias: 90 kDa ribosomal protein S6 kinase 2; 90kDa; D17Wsu134e; HU-2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1C; MAPKAPK1C; MAPKAPK-1c; mitogen-activated protein kinase-activated protein kinase 1C; p90rsk; p90-RSK 2; p90RSK2; p90-RSK3; pp90rsk; pp90RSK3; Protein-tyrosine kinase Mpk-9; ribosomal protein S6 kinase A2; ribosomal protein S6 kinase alpha 2; ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase polypeptide 2; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; ribosomal protein S6 kinase, polypeptide 2; ribosomal S6 kinase 3; Rps6ka2; Rps6ka-rs1; RSK; Rsk3; RSK-3; S6K-alpha; S6K-alpha 2; S6K-alpha2; S6K-alpha-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20112, 6196
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.35 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q15349, Q9WUT3
• Gene Symbols: RPS6KA2
• Immunogen: Carrier-protein conjugated synthetic peptide surrounding phospho Thr356/Ser360 of human RSK3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG