Phospho-RBL1 (Thr369) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538423

Product Code. 15505351

Description

RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.

Specifications

• Antigen: Phospho-RBL1 (Thr369)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RBL1
• Gene Alias: Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, PRB1, P107, RBL1,
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19650, 5933
• Content And Storage: -20°C
• Form: Liquid

• Applications: Peptide ELISA
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P28749, Q64701
• Gene Symbols: RBL1
• Immunogen: A synthetic phosphopeptide derived from human RBL1 around the phosphorylation site of Thr369 (P-S-TP-P-L)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG