missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. Invitrogen™ Phospho-PTS (Ser19) Recombinant Rabbit Monoclonal Antibody (K01_2L10)

Invitrogen™ Phospho-PTS (Ser19) Recombinant Rabbit Monoclonal Antibody (K01_2L10)

Product Code. 30826384
Change view
Click to view available options
Quantity:
50 μL
100 μL
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity
30826384 100 μL
30828065 50 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 30826384 Supplier Invitrogen™ Supplier No. MA563981

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Rabbit Recombinant Monoclonal Antibody

Phospho-PTS (Ser19) Recombinant Monoclonal Antibody for IHC (P), Western Blot

The tetrahydrobiopterin (BH4) cofactor is essential for hepatic hydroxylase, which is involved in phenylalanine degradation and catecholamine and serotonin biosynthesis. BH4 is also an essential and limiting cofactor for all types of nitric oxide synthase. BH4 deficiency results in hyperphenylalaninemia and monoamine neurotransmitter depletion and is most commonly due to autosomal recessive mutation in 6-pyruvoyltetrahydropterin synthase (PTPS), the second enzyme for BH4 biosynthesis. The active site of PTPS consists of the pterin-anchoring Glu A107 neighbored by two catalytic motifs: a Zn(II) binding site and an inter-subunit catalytic triad formed by Cys A42, Asp B88 and His B89. The active site of PTPS undergoes a Zn and Mg-dependent reaction that includes a triphosphate elimination, a stereospecific reduction and the oxidation of both side hydroxyl groups. The catalytic triad of PTPS is involved in the deprotonation of the side-chain carbons of substrates. In addition, Ser 19 of human PTPS may be a substrate for cGMP-dependent protein kinase type II phosphorylation in vivo, which is essential for normal activity of PTPS.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PTS (Ser19)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone K01_2L10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 40% glycerol, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene Pts
Gene Accession No. Q03393
Gene Alias 6-pyruvoyl tetrahydrobiopterin synthase; 6-pyruvoyltetrahydropterin synthase; 6-pyruvoyl-tetrahydropterin synthase; PTP synthase; PTPS; PTS
Gene Symbols Pts
Host Species Rabbit
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser19 of human PTS/PTPS.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5805
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.