Phospho-PKD1/2/3/PKC mu (Ser738, Ser742) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538386

Product Code. 15535311

Description

PKC mu (protein kinase C mu, PRKD1) is a serine/threonine kinase whose activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway. In addition to the two activation loop sites, the carboxy-terminal Ser916 has been identified as an autophosphorylation site for PKD/PKCu. Phosphorylation at Ser916 correlates with PKD/PKCu catalytic activity. PKC mu is one of the PKC family members, and the protein binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Members of the protein kinase C (PKC) family function in many extracellular receptor-mediated signal transduction pathways.

Specifications

• Antigen: Phospho-PDK/PKC mu (Ser738, Ser742)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKD1
• Gene Alias: Serine/threonine-protein kinase D1, Protein kinase C mu type, Protein kinase D, nPKC-D1, nPKC-mu, PRKD1, PKD, PKD1, PRKCM, PKCu, PKC u, PKC-u, Serine/threonine-protein kinase D2, nPKC-D2, PRKD2, PKD2, HSPC187, PKC mu, PKCmu, Serine/threonine-protein kinase D3, Protein kinase C nu type, Protein kinase EPK2, nPKC-nu, PRKD3, EPK2, PRKCN, PKD3, PKCv, PKC v, PKC-v, PKC nu, PKCnu, PKC-nu
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25865, 292658, 5587, 85421, 101540, 18607, 313834, 81745, 5170, 18760, 23683, 75292
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8BZ03, Q5XIS9, Q62101, O94806, Q9BZL6, Q15139, Q9WTQ1, Q9Z2A0, O15530, O55173, Q8K1Y2
• Gene Symbols: PDPK1, Prkd1, PRKD2, PRKD3
• Immunogen: A synthetic phosphopeptide derived from human PKD1/2/3/PKC mu around the phosphorylation site of Ser738 and Ser742 (E-K-SP-F-R-R-SP-V-V)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG