Phospho-PKC mu (Tyr463) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5104995

Product Code. 16621445

Description

Antibody detects endogenous levels of PKD1/PKC mu only when phosphorylated at Tyrosine 463.

The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.

Specifications

• Antigen: Phospho-PKC mu (Tyr463)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKD1
• Gene Alias: 4930557O20Rik; 5730497N19Rik; AI325941; DKFZP586E0820; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; Pkcm; PKCmu; PKC-MU; Pkcnu; PKC-NU; PKCu; PKC-u; PKCv; PKC-v; Pkd; PKD1; PKD2; PKD3; Prkcm; PRKCN; Prkd1; PRKD2; PRKD3; Protein kinase C mu type; protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; protein kinase D; protein kinase D1; protein kinase D2; protein kinase D3; protein kinase EPK2; RGD1308054; Serine/threonine-protein kinase D1; serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101540, 18760, 23683, 25865, 292658, 313834, 5587, 75292, 85421
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O94806, Q15139, Q5XIS9, Q62101, Q8BZ03, Q8K1Y2, Q9BZL6, Q9WTQ1
• Gene Symbols: PRKD1, Prkd2, Prkd3
• Immunogen: A synthesized peptide derived from human PRKD1(Accession Q15139), corresponding to amino acid residues around phosphorylated Tyr463.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG