Invitrogen™ Phospho-PKA alpha/beta/gamma (Thr197) Recombinant Rabbit Monoclonal Antibody (24GB1650)

Product Code.	Quantity	unitSize
30275556	20 μL	20µL
30275561	100 μL	100µL

Product Code. 30275556 Supplier Invitrogen™ Supplier No. MA556937

Description

Rabbit Recombinant Monoclonal Antibody

Phospho-PKA alpha/beta/gamma (Thr197) Recombinant Monoclonal Antibody for Western Blot, Flow

Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior. PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers. The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors. However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.

Specifications

• Antigen: Phospho-PKA alpha/beta/gamma (Thr197)
• Applications: Flow Cytometry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 24GB1650
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: PRKACA
• Gene Accession No.: P05132, P17252, P22612, P22694, P27791, P68181, P68182
• Gene Alias: BDPLT19; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; cAMP-dependent protein kinase catalytic subunit beta; cAMP-dependent protein kinase catalytic subunit gamma; KAPG; PKA C-alpha; PKA C-beta; PKA C-gamma; PKACA; PKACB; PKACg; PPNAD4; PRKACA; PRKACB; PRKACG; protein kinase A catalytic subunit; protein kinase A catalytic subunit beta; protein kinase cAMP-activated catalytic subunit alpha; protein kinase cAMP-activated catalytic subunit beta; protein kinase cAMP-activated catalytic subunit gamma; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, beta; protein kinase, cAMP-dependent, catalytic, gamma; protein kinase, cAMP-dependent, gamma catalytic subunit; serine(threonine) protein kinase
• Gene Symbols: PRKACA, PRKACB, PRKACG
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human Phospho-PKA C (Thr197) (aa 190-204).
• Purification Method: Affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18747, 18749, 25636, 293508, 5566, 5567, 5568
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG