Invitrogen™ Phospho-PKD1/2/3/PKC mu (Ser738, Ser742) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA537822

Product Code. 15534761

Description

A suggested positive control for Western blot is A549 cells.

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane.

Specifications

• Antigen: Phospho-PKD1/2/3/PKC mu (Ser738, Ser742)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKD1
• Gene Alias: 4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; Pkcm; PKC-MU; Pkcnu; PKC-NU; PKD; PKD1; PKD2; PKD3; Prkcm; Prkcn; Prkd1; PRKD2; Prkd3; Protein kinase C mu type; protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; protein kinase D; protein kinase D1; protein kinase D2; protein kinase D3; protein kinase EPK2; RGD1308054; Serine/threonine-protein kinase D1; serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101540, 18760, 23683, 25865, 292658, 313834, 5587, 75292, 85421
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O94806, Q15139, Q5XIS9, Q62101, Q8BZ03, Q8K1Y2, Q9BZL6, Q9WTQ1
• Gene Symbols: PRKD1, PRKD2, PRKD3
• Immunogen: Peptide sequence around phosphorylation site of Serine738/Serine 742 (E-K-S(p)-F-R-R-S(p)-V-V) derived from Human PKD1/2/3/PKC mu.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG