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Phospho-Paxillin (Ser83) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5143736

Additional Details : Weight : 0.01000kg

Product Code. 17836958

  • £426.00 / 100µL
Estimated Shipment: 20-08-2024
to see stock.

Description

Description

The antibody detects a 68kDa* protein corresponding to the molecular mass of phosphorylated paxillin on SDS-PAGE immunoblots of NGF treated rat PC12 cells, as well as calyculin A treated human A431 cells and mouse macrophages.

Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
Specifications

Specifications

Phospho-Paxillin (Ser83)
Polyclonal
Unconjugated
PXN
adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; pxn; pxna; testicular tissue protein Li 134; TGFB1I1; transforming growth factor beta 1 induced transcript 1; wu:fw71f12
Rabbit
Antigen affinity chromatography
RUO
19303
-20° C, Avoid Freeze/Thaw Cycles
IgG
Immunocytochemistry, Western Blot
Lot-Specific
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Q8VI36
PXN
Phospho-Paxillin (Ser-83) synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 83 of mouse paxillin. This sequence is highly conserved in rat and human paxillin and is also found in all isoforms (a, b, g) of paxillin.
100 μL
Primary
Mouse
Liquid
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