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Phospho-Paxillin (Ser83) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5143736
This item is not returnable.
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Description
The antibody detects a 68kDa* protein corresponding to the molecular mass of phosphorylated paxillin on SDS-PAGE immunoblots of NGF treated rat PC12 cells, as well as calyculin A treated human A431 cells and mouse macrophages.
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
Specifications
| Phospho-Paxillin (Ser83) | |
| Polyclonal | |
| Unconjugated | |
| PXN | |
| adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; pxn; pxna; testicular tissue protein Li 134; TGFB1I1; transforming growth factor beta 1 induced transcript 1; wu:fw71f12 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 19303 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| IgG |
| Immunocytochemistry, Western Blot | |
| Lot-Specific | |
| PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide | |
| Q8VI36 | |
| PXN | |
| Phospho-Paxillin (Ser-83) synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 83 of mouse paxillin. This sequence is highly conserved in rat and human paxillin and is also found in all isoforms (a, b, g) of paxillin. | |
| 100 μL | |
| Primary | |
| Mouse | |
| Liquid |