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  6. Invitrogen™ Phospho-PAK4/6/7 (Ser474, Ser560, Ser602) Recombinant Rabbit Monoclonal Antibody (K01_2Q24)

Invitrogen™ Phospho-PAK4/6/7 (Ser474, Ser560, Ser602) Recombinant Rabbit Monoclonal Antibody (K01_2Q24)

Product Code. 30830010
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30826643 50 μL
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Product Code. 30830010 Supplier Invitrogen™ Supplier No. MA564255
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Estimated Shipment: 17-11-2026
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Description

Rabbit Recombinant Monoclonal Antibody

Phospho-PAK4/6/7 (Ser474, Ser560, Ser602) Recombinant Monoclonal Antibody for Western Blot

PAK4 is highly expressed in prostate, testis and colon. PAK4 interacts tightly with GTP-bound but not GDP-bound CDC42 and weakly with RAC. PAK4 phosphorylates and autophosphorylates and also activates the JNK pathway. PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAK4/6/7 (Ser474, Ser560, Ser602)
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_2Q24
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 0.05% BSA, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene Pak4
Gene Accession No. D4A280, O96013, Q3ULB5, Q8BTW9, Q8C015, Q9NQU5, Q9P286
Gene Alias 2900083L08Rik; 4732456M09; 5730488L07Rik; 6430627N20; AW555722; KIAA1142; KIAA1264; mKIAA1142; p21 (CDKN1A)-activated kinase 4; p21 (CDKN1A)-activated kinase 6; p21 (CDKN1A)-activated kinase 7; p21 (RAC1) activated kinase 4; p21 (RAC1) activated kinase 5; p21 (RAC1) activated kinase 6; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 4; p21(CDKN1A)-activated kinase 6; p21(CDKN1A)-activated kinase 7; p21-activated kinase 4; p21-activated kinase 5; p21-activated kinase 6; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK 4/5/6; PAK 4/6/7; PAK4; PAK-4; PAK4/5/6; PAK5; PAK-5; PAK6; PAK-6; Pak7; PAK-7; protein kinase PAK5; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4; Serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 6; serine/threonine-protein kinase PAK 6-like; serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7
Gene Symbols Pak4, PAK5, PAK6, Pak7
Host Species Rabbit
Immunogen A synthesized peptide derived from human Phospho-PAK4+PAK5+PAK6 (S474+S560+S602).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10298, 214230, 241656, 292756, 296078, 311450, 56924, 57144, 70584
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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