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Phospho-PAK2 (Ser141) Polyclonal Antibody, Invitrogen™

Product Code. 15526621
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Quantity:
100 μg
Unit Size:
100µg
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15526621 100 μg 100µg
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Product Code. 15526621 Supplier Invitrogen Supplier No. PA539750

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Description

Rabbit Polyclonal Antibody

Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAK2 (Ser141)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PAK2
Gene Accession No. Q13177, Q8CIN4, Q64303
Gene Alias Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, PAK1, PAK alpha, Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, PAK-2, p58, PAK-2p27, PAK-2p34, C-t-PAK2, PAK2, PAK gamma, Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3, PAK beta
Gene Symbols PAK2
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human PAK2 around the phosphorylation site of Ser141 (Y-L-SP-F-T)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 224105, 29432, 5062
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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