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Invitrogen™ Phospho-PAK1/PAK2 (Thr423, Thr402) Polyclonal Antibody
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Product Code. 15544141
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Quantity:
100 μL
Unit Size:
100µL
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15544141 100 μL 100µL
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Product Code. 15544141 Supplier Invitrogen™ Supplier No. PA536888

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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 60-70 kDa. Purity is >95% by SDS-PAGE.

Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAK1/PAK2 (Thr423, Thr402)
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide; pH 7.2
Gene Pak1
Gene Accession No. O88643, P35465, Q13153, Q13177, Q64303, Q8CIN4
Gene Alias 5330420P17Rik; A130002K10Rik; activated protein kinase alpha; AI836325; Alpha-PAK; AW045634; Beta-PAK; CDC42/RAC effector kinase PAK-A; C-t-PAK2; D16Ertd269e; gamma pak; gamma-PAK; mKIAA4182; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21-activated kinase 1; p21-activated kinase 2; p27; p34; p58; p65-PAK; p68-PAK; PAK alpha; PAK beta; PAK gamma; PAK1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK65; Paka; PAKalpha; PAKgamma; Protein kinase MUK2; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 2; STE20 homolog, yeast
Gene Symbols Pak1, PAK2
Host Species Rabbit
Immunogen Synthetic phosphopeptide derived from human PAK1 around the phosphorylation site of Threonine 423.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18479, 224105, 29431, 29432, 5058, 5062
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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