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Invitrogen™ Phospho-PAK1/2/3 (Thr402) Polyclonal Antibody

Product Code. 11543431
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Quantity:
100 μL
Unit Size:
100µL
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11543431 100 μL 100µL
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Product Code. 11543431 Supplier Invitrogen™ Supplier No. PA14636

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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with bovine, canine, human and mouse based on 100% sequence homology. This antibody is specific for the ~68 kDa to ~70 kDa PAK phosphorylated at Thr402. Immunolabeling can be blocked by lambda-phosphatase treatment.

In mammals, there are several identified isoforms of p21-Activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated wit X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAK1/2/3 (Thr402)
Applications Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 50% glycerol, 100μg/mL BSA, 0.15M NaCl and no preservative; pH 7.5
Gene Pak1
Gene Accession No. O88643, P35465, Q61036, Q62829, Q64303, Q8CIN4
Gene Alias 5330420P17Rik; A130002K10Rik; activated protein kinase alpha; ADRB2; adriamycin resistance-associated; AI836325; Alpha-PAK; aPAK; ARA; AW045634; Beta-PAK; bPAK; CDC42/RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-B; CDKN1A; CLAP; C-t-PAK2; D16Ertd269e; EC 2.7.11.1; gamma pak; gamma-PAK; hPAK3; kinase PAK1; mKIAA4182; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 1; p21-activated kinase 2; p21-activated kinase 3; p27; p34; p58; p65-PAK; p68-PAK; PAK 1; PAK alpha; PAK beta; PAK gamma; Pak1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK3beta; PAK65; Pak65alpha; Pak65beta; Paka; PAK-a; PAKalpha; Pakb; PAK-B; PAKgamma; PAK-y; Protein kinase MUK2; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; STE20 homolog, yeast; Stk4; yPAK
Gene Symbols Pak1, PAK2, PAK3
Host Species Rabbit
Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr402 of rat PAK1-3 conjugated to KLH.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18479, 18481, 224105, 29431, 29432, 29433
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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