Invitrogen™ Phospho-ASAP2 (Tyr724) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ 44716G

Product Code. 10682384

Description

Phospho-ASAP2 (Tyr724) Polyclonal Antibody for Western Blot

ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found.

Specifications

• Antigen: Phospho-ASAP2 (Tyr724)
• Classification: Polyclonal
• Formulation: Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
• Gene Accession No.: O43150
• Gene Symbols: ASAP2
• Immunogen: The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PAG3 that contains tyrosine 724.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: ASAP2
• Gene Alias: 6530401G17Rik; AMAP2; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Asap2; centaurin, beta 3; CENTB3; DDEF2; development and differentiation enhancing factor 2; development and differentiation-enhancing factor 2; Gm1523; Gm592; KIAA0400; PAG3; PAP; Pap-alpha; PAPbeta; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; pyk2 C-terminus-associated protein; SHAG1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8853
• Content And Storage: -20°C
• Form: Liquid