Invitrogen™ Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5121361

Product Code. 17792754

Description

Positive test controls include: C6. Immunogen sequence: MTGYV.

The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

Specifications

• Antigen: Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAPK13
• Gene Symbols: MAPK11, MAPK12, MAPK13, MAPK14
• Immunogen: Synthetic peptide.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 0.26 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O15264, P53778, P70618, Q15759, Q16539, Q63538, Q9WTY9
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1432, 29513, 5600, 5603, 60352, 6300, 689314, 81649
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid