Invitrogen™ Phospho-NFATC2 (Ser53) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5114611

Product Code. 17267373

Description

Antibody detects endogenous levels of NFAT1 only when phosphorylated at Ser53.

The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.

Specifications

• Antigen: Phospho-NFATC2 (Ser53)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFATC2
• Gene Alias: AI607462; IB-IXL; KIAA0611; NFAT pre-existing s; NFAT pre-existing subunit; NFAT transcription complex, preexisting component; Nfat1; NFAT1-D; Nfatc2; NF-ATc2; Nfatp; NF-ATp; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; nuclear factor of activated T-cells 2; nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; OTTHUMP00000031291; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4773
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q13469
• Gene Symbols: NFATC2
• Immunogen: A synthesized peptide derived from human NFAT1 around the phosphorylation site of Ser53.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG