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Invitrogen™ Phospho-MLK3 (Thr277, Ser281) Polyclonal Antibody
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Product Code. 16644535
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Quantity:
100 μL
Unit Size:
100µL
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16644535 100 μL 100µL
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Product Code. 16644535 Supplier Invitrogen™ Supplier No. PA5105817

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of MLK3 only when phosphorylated at Thr277+Ser281.

MAP3K11 (MLK3) is a serine/threonine kinase that activates both the p38 MAP kinase and c-Jun kinase pathways. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-MLK3 (Thr277, Ser281)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MAP3K11
Gene Accession No. Q16584, Q66HA1, Q80XI6
Gene Alias 2610017K16Rik; MAP3K11; MEKK11; MGC17114; mitogen activated protein kinase kinase kinase 11; mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Mlk3; MLK-3; protein-tyrosine kinase PTK1; PTK1; RHOE; SH3 domain-containing proline-rich kinase; SPRK; Src-homology 3 domain-containing proline-rich kinase
Gene Symbols MAP3K11
Host Species Rabbit
Immunogen A synthesized peptide derived from human MAP3K11(Accession Q16584), corresponding to amino acid residues around phosphorylated Ser281.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26403, 309168, 4296
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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