Invitrogen™ Phospho-MKK7 (Thr275) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102908

Product Code. 16629364

Description

Antibody detects endogenous levels of MKK7 only when phosphorylated at Thr275.

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Specifications

• Antigen: Phospho-MKK7 (Thr275)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP2K7
• Gene Alias: 2; 5930412N11Rik; c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; EMBL:AAX61178.1}; JN; JNK kinase 2; JNK-activating kinase 2; JNKK; JNKK 2; Jnkk2; MAP kinase kinase 7; MAP2K4; map2k7; map2k7 {ECO:0000312; MAPK/ERK kinase 4; MAPK/ERK kinase 7; MAPKK 4; MAPKK 7; MAPKK7; MEK; MEK 4; MEK 7; Mek7; mitogen activated protein kinase kinase 7; mitogen-activated protein kinase kinase 7; Mkk7; PRKMK7; protein kinase, mitogen activated, kinase 7; SAPK kinase 1; SAPK kinase 4; SAPK/ERK kinase 1; SAPKK1; SAPKK-1; SAPKK4; SAPKK-4; SEK1; sek2; SKK4; Stress-activated protein kinase kinase 4
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26400, 363855, 5609
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O14733, Q4KSH7, Q8CE90
• Gene Symbols: MAP2K7
• Immunogen: A synthesized peptide derived from human MAP2K7(Accession O14733), corresponding to amino acid residues around phosphorylated Thr275.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG