Invitrogen™ Phospho-MARK Pan (Thr215) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5105814

Product Code. 16672255

Description

Antibody detects endogenous levels of MARK1/2/3/4 only when phosphorylated at Thr215.

MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.

Specifications

• Antigen: Phospho-MARK Pan (Thr215)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MARK3
• Gene Alias: 1600015G02Rik; 2410090P21Rik; A430080F22Rik; AW491150; B930025N23Rik; C79806; Cdc25C-associated protein kinase 1; cTAK1; C-TAK1; ELKL motif kinase 1; ELKL motif kinase 2; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk; EMK1; EMK-1; Emk2; EMK-2; EMK2/MARK3 serine-threonine protein kinase; Emk3; ETK1; ETK-1; KIAA1477; Kiaa1860; KP78; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity regulating kinase 2; MAP/microtubule affinity regulating kinase 3; MAP/microtubule affinity regulating kinase 4; MAP/microtubule affinity-regulating kinase 1; MAP/microtubule affinity-regulating kinase 2; MAP/microtubule affinity-regulating kinase 3; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase 4L; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK; MARK1; mark1 {ECO:0000312; MARK2; mark2 {ECO:0000312; MARK3; MARK4; MARK4 serine/threonine protein kinase; MARK4L; MARK4S; MARKL1; MARKL1L; microtubule affinity regulating kinase 1; microtubule affinity regulating kinase 2; microtubule affinity regulating kinase 3; microtubule affinity regulating kinase 4; mKIAA1477; mPar-1c; MPK10; MPK-10; Par-1; PAR1 homolog; PAR1 homolog b; PAR1 homolog c; PAR1A; Par-1a; Par1b; Par-1b; Par1c; Par-1c; PAR-1D; protein kinase STK10; RGD:619882}; RGD:708483}; Ser/Thr protein kinase PAR-1; Ser/Thr protein kinase PAR-1B; serine/threonine kinase; serine/threonine protein kinase EMK; serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase MARK2; serine/threonine-protein kinase p78; testicular tissue protein Li 117
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117016, 13728, 170577, 17169, 2011, 226778, 232944, 4139, 4140, 57787, 60328, 680407
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O08678, O08679, P27448, Q03141, Q05512, Q7KZI7, Q8CIP4, Q8VHF0, Q8VHJ5, Q96L34, Q9P0L2
• Gene Symbols: MARK1, MARK2, MARK3, MARK4
• Immunogen: A synthesized peptide derived from human MARK1(Accession Q9P0L2), corresponding to amino acid residues around phosphorylated Thr215.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG