Invitrogen™ Phospho-LIN28A (Ser200) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5105696

Product Code. 16692135

Description

Antibody detects endogenous levels of LIN28A only when phosphorylated at Ser200.

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Specifications

• Antigen: Phospho-LIN28A (Ser200)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LIN28A
• Gene Alias: AL024421; CSDD1; ENSMUSG00000070700; FLJ12457; Gm10299; Lin28; LIN-28; lin-28 homolog A; lin-28 homolog A (C. elegans); Lin28a; lin-28A; Protein lin-28 homolog A; RGD1566408; RNA-binding protein LIN-28; sb:cb650; si:ch211-232d9.4; similar to RNA-binding protein LIN-28; testis expressed gene 17; testis-expressed protein 17; Tex17; ZCCHC1; zgc:55584; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79727, 83557
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8K3Y3, Q9H9Z2
• Gene Symbols: LIN28A
• Immunogen: A synthesized peptide derived from human LIN28A(Accession Q9H9Z2), corresponding to amino acid residues around phosphorylated Ser200.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG