Invitrogen™ Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA538078

Product Code. 15595001

Description

Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody for Western Blot, IHC (P)

Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.

Specifications

• Antigen: Phospho-LIMK1/LIMK2 (Thr508, Thr505)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LIMK1
• Gene Alias: KIZ-1; LIM domain kinase 1; LIM domain kinase 2; lim kinase 1; LIM kinase 2; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM motif-containing protein kinase 2; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase; LIM-domain containing, protein kinase 1; Limk; LIMK 2; LIMK1; LIMK-1; LIMK2; LIMK-2; Limk2b; Link2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16885, 16886, 29524, 3984, 3985, 65172
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O54785, P53667, P53668, P53669, P53670, P53671
• Gene Symbols: LIMK1, LIMK2
• Immunogen: A synthetic phosphopeptide derived from human LIMK1/2 around the phosphorylation site of Thr508/505.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG